发明名称 Macrocyclic peptides active against the hepatitis C virus.
摘要 Compounds of formula I: wherein R<1 >is hydroxy or NHSO2R<1A >wherein R<1A >is (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O(C1-6)alkyl, amido, amino or phenyl, or R<1A >is C6 or C10 aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O(C1-6)alkyl, amido, amino or phenyl; R<2 >is (C5-6)cycloalkyl and R<3 >is cyclopentyl; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.
申请公布号 ZA200405639(B) 申请公布日期 2005.07.01
申请号 ZA20040005639 申请日期 2004.07.15
申请人 BOEHRINGER INGELHEIM (CANADA) LTD. 发明人 MONTSE LLINAS-BRUNET;GORYS, VIDA, J.
分类号 A61K45/00;A61K31/7052;A61K38/00;A61K38/21;A61P31/14;A61P43/00;C07K5/078;C07K5/083;C07K5/087 主分类号 A61K45/00
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