Oligonucleotide conjugates, process for detecting a target structure, use of these compounds and diagnosis kit

摘要

Described are oligonucleotide conjugates consisting of an oligonucleotide radical N and n substituents (B-K), in which the compound exhibits general formula (I), in which N is an oligonucleotide with 15 to 100 nucleotides, which bonds specifically with high bonding affinity to target structures and exhibits modifications that prevents or at least significantly reduce the degradation by naturally occurring nucleases, n is a number between 1 and 10, B is a chemical bond or a connecting component, which produces the connection between N and K, and K means a complexing agent or complex of radioactive metal isotopes, or stable isotopes, which a) are converted by radiation from outside to radioactive isotopes, b) convert radiation from outside to radiation of different quality, different energy content and/or different wavelength, of elements of atomic numbers 5, 21 to 29, 31, 39, 42 to 44, 49, 57 to 83 or 85. The compounds are used for non-invasive diagnosis of diseases, for the production of a medicament useful in radiodiagnosis and/or in radiotherapy and also is described a process for detecting a target structure and kit for in vivo and/or vitro detection of target structures comprises these compounds.