发明名称 |
TRANSDERMAL DELIVERY SYSTEM OF HORMONES WITHOUT PENETRATION ENHANCERS |
摘要 |
The present invention relates to a patch comprising a drug-containing layer with low content of hormones, such as gestodene, and optionally an estrogen (e.g. ethinyl estradiol). Upon administering the patch to a woman, plasma levels of at least 1.0 ng/ml of Gestodene is achieved at steady state conditions without the need of incorporating penetration enhancers or permeation enhancers in the drug-containing layer. Satisfactorily plasma levels of the hormones is also achieved throughout a period of at least 1 week, making the patch applicable for being used in female contraception with the concept of administering the patch ones weekly. |
申请公布号 |
CA2549916(A1) |
申请公布日期 |
2005.06.30 |
申请号 |
CA20042549916 |
申请日期 |
2004.12.10 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
BRACHT, STEFAN;DITTGEN, MICHAEL;SCHENK, DIRK;LANGGUTH, THOMAS;HUBER, PETRA |
分类号 |
A61K9/70;A61K31/56;A61K31/565;A61P15/18 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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