| 发明名称 |
Mutant interleukin-2 (IL-2) polypeptides |
| 摘要 |
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Ralpha). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2alpha using yeast surface display to generate mutants with increased affinity for IL-2Ralpha.
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| 申请公布号 |
US2005142106(A1) |
申请公布日期 |
2005.06.30 |
| 申请号 |
US20040894833 |
申请日期 |
2004.07.19 |
| 申请人 |
WITTRUP K. D.;RAO BALAJI M.;LAUFFENBURGER DOUGLAS A. |
发明人 |
WITTRUP K. D.;RAO BALAJI M.;LAUFFENBURGER DOUGLAS A. |
| 分类号 |
A61K;A61K38/20;C07H21/04;C07K14/55;C12P21/04;(IPC1-7):C07K14/55 |
主分类号 |
A61K |
| 代理机构 |
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