发明名称 |
Controlled release bead, a method of producing the same and multiple unit formulation comprising it |
摘要 |
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.
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申请公布号 |
US6911217(B1) |
申请公布日期 |
2005.06.28 |
申请号 |
US20010763281 |
申请日期 |
2001.05.05 |
申请人 |
PHARMACIA AB |
发明人 |
GREN TORKEL;RINGBERG ANDERS;WIKBERG MARTIN;WALD RANDY J. |
分类号 |
A61K;A61K9/50;A61K9/52;A61K9/70;A61K31/137;A61P;A61P13/10;(IPC1-7):A61K9/00;A61K9/54;A61K9/56;A61K31/135 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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