发明名称 |
Compounds that inhibit the interaction between signal-transducing proteins and the GLGF (PDZ/DHR) domain and uses thereof |
摘要 |
This invention provides for a composition capable of inhibiting specific binding between a signal-transducing protein and a cytoplasmic protein. This invention also provides a method of identifying a compound capable of inhibiting specific binding between a signal-transducing protein and a cytoplasmic protein. This invention also provides a method of inhibiting the proliferation of cancer cells. This invention also provides a method of treating cancer with a composition in an amount effective to result in an amount in apoptosis of the cells. This invention also provides a method of inhibiting the proliferation of virally infected cells. This invention also provides for a method of treating a virally-infected subject with a composition in an amount effective to result in apoptosis of the cells. This invention also provides for pharmaceutical compositions.
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申请公布号 |
US6911526(B2) |
申请公布日期 |
2005.06.28 |
申请号 |
US19960681219 |
申请日期 |
1996.07.22 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
SATO TAKAAKI;YANAGISAWA JUNN |
分类号 |
A61K45/00;A61K38/00;A61K38/08;A61P31/12;A61P35/00;A61P43/00;C07K5/10;C07K7/06;C07K7/08;C07K14/47;G01N33/50;(IPC1-7):C07K7/08;C07K14/705 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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