БЛОК-СОПОЛИМЕР С ПОНИЖЕННЫМ СОДЕРЖАНИЕМ ПРИМЕСЕЙ, ПОЛИМЕРНЫЙ НОСИТЕЛЬ, ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ В ПОЛИМЕРНОЙ ФОРМЕ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

摘要

Block copolymer or salt thereof comprises polyethylene glycol and polyacidic amino acid and 10 wt% impurity. Independent claims are also included for: (1) preparation of a copolymer or salt thereof, by refining polyethylene glycol derivative with ion exchange resin, removing protective group if necessary, and treating with absorbing resin; (2) a polymer carrier wherein the polyacidic amino acid is condensed with anthra cycling type caner controlling residual groups; (3) preparation of the carrier; and (4) a polymer medicine comprising a block copolymer-medicine composite wherein anthra cycling cancer controlling agent is wrapped in the core of a polymer micelle.