Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug

摘要

A block copolymer of formula (I): A-B-L-X-M that is used as a drug carrier for an anionic drug is disclosed, wherein X represents a cationic group, M represents an anion, A is a biocompatible hydrophilic polymer, B is a biodegradable hydrophobic polymer, and L represents a linker selected from the group consisting of -O-, -NH-, -S- and -COO-. When this biocompatible and biodegradable cationic group-containing amphiphilic block copolymer is used as a drug carrier for an anionic drug, it provides several advantages such as increased blood concentration and improved stability of the drug.