Pyrazole compounds useful as protein kinase inhibitors

摘要

Pyrazole compounds of formula (III) are disclosed, wherein Z1, Z2, and Z3 are as defined in the specification; Q is -S-, -O-, -N(R4)-, or -CH(R6)-; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl; and R2, R2' R4 and R6 are as defined in the specification. These compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.