Composition, useful for prophylaxis and/or treatment of Alzheimer's disease, comprises sphingosine, sphingosine biosynthesis activator or sphingosine biodegradation inhibitor

摘要

A composition (I) for the prophylaxis and/or treatment of Alzheimer's disease contains (a) at least one sphingosine, (b) at least one activator of endogenous sphingosine synthesis in the body and/or (c) at least one inhibitor of sphingosine degradation in the body. ACTIVITY : Neuroprotective; Nootropic. MECHANISM OF ACTION : Amyloid-beta peptide (Abeta ) concentration reducer; Abeta formation inhibitor. In tests in cultures of mouse primary neurones transfected with the SPA4CT gene (encoding an abbreviated form of amyloid precursor protein (APP), which is converted into Abeta by secretases) in N2-MEM medium, addition of sphingosine to the medium at 10 mu M reduced the Abeta level after 24 hours by 90%.