PATCH

摘要

A patch device adapted for use in the transdermal administration to a patient of a composition including, or consisting of, a selected irritating substance, preferably dimethylformamide or DMF, the patch consisting of a layered construct adapted to be adhered to the skin of a patient and defining a depot cavity for the composition to be administered between a proximal layer and a distal layer thereof, which proximal layer is adapted in use to be located in intimate contact with the skin of the patient and which distal layer is in use disposed on the outer side thereof, the distal layer being characterised in that it is substantially impervious to the composition to be administered, and the proximal layer being characterised in that it is partially permeable to that composition, so that in use the composition may be disposed in the cavity and permeate from there through the proximal layer to be absorbed through the skin into the body of the patient, the proximal layer being further characterised in that its permeability to the irritating substance or component of such composition is less than the permeability of the patients skin to such irritating substance.