DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER
摘要
<p>The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.</p>
申请公布号
WO2005053662(A1)
申请公布日期
2005.06.16
申请号
WO2004GB05025
申请日期
2004.11.30
申请人
KUDOS PHARMACEUTICALS LIMITED;THE INSTITUTE OF CANCER RESEARCH;ASHWORTH, ALAN;JACKSON, STEPHEN;MARTIN, NIALL;SMITH, GRAEME