发明名称 |
PROCESS FOR PURIFYING CITALOPRAM USING POLYBASIC ACIDS |
摘要 |
A process of purifying citalopram, either in racemic or enantiomeric form, which process comprises (i) providing a crude mixture comprising citalopram, either in racemic or enantiomeric form, dissolved in a water immiscible organic solvent, and which mixture also includes one or more citalopram derivatives which are present as citalopram. impurities; (ii) washing the crude mixture with at least one dilute aqueous solution of a polybasic acid, either in free form or as a partial alkali metal salt, so as to separate citalopram from citalopram impurities present in the crude mixture; and (iii) where required converting citalopram free base, separated from citalopram impurities further to step (ii), to a pharmaceutically acceptable salt. |
申请公布号 |
WO2005012278(A3) |
申请公布日期 |
2005.06.16 |
申请号 |
WO2004GB03209 |
申请日期 |
2004.07.23 |
申请人 |
MEDITAB SPECIALITIES PVT. LTD;UTTARWAR, SUNIL, GOVINDRAO;GAWLI, BHAGWAN, NARAYAN;WAIN, CHRISTOPHER, PAUL |
发明人 |
UTTARWAR, SUNIL, GOVINDRAO;GAWLI, BHAGWAN, NARAYAN |
分类号 |
A61K31/34;C07D307/87 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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