HUMAN STEM CELL DERIVED FROM PLACENTA OR AMNION AND METHOD FOR ESTABLISHING THE SAME AND METHOD FOR DIFFERENTIATION-INDUCTION TO ORGAN

摘要

PROBLEM TO BE SOLVED: To provide a human stem cell enabling passage (≥30 times) having sufficient number of times as a stem cell from human placenta or amnion treated as a waste when delivered.

SOLUTION: The human stem cell has the following cell biological characteristics. (1) The stem cell is derived from placenta or amnion. (2) The stem cell has a karyotype of normal diplont. (3) The stem cell continues proliferation in an undifferentiated state. (4) Alkaline phosphatase activity is positive. (5) The stem cell expresses transcription factors Rex-1, Oct-4 and Ecat-4. (6) The stem cell enables passage of≥30 times while keeping multipotency.

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