发明名称 |
HETERODIMEREBILDENDE HYBRID-PROTEINE |
摘要 |
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-beta and TPO, linked to alpha subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins. |
申请公布号 |
AT295887(T) |
申请公布日期 |
2005.06.15 |
申请号 |
AT19970906604T |
申请日期 |
1997.02.20 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
CAMPBELL, ROBERT, K.;JAMESON, BRADFORD, A.;CHAPPEL, SCOTT, C. |
分类号 |
A61K38/00;A61K38/24;C07C209/22;C07K14/59;C07K14/715;C07K14/72;C07K16/46;C12N5/10;C12N15/16;C12N15/62;C12N15/85;C12P21/04;(IPC1-7):C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|