发明名称 |
A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT |
摘要 |
A process for the preparation of polymorph A of zofenopril calcium salt in substantially pure form, which comprises: a) reaction of S(-)-3-benzoylthio-2-methylpropanoic acid chloride with cis-4-phenylthio-L-proline in water at pH ranging from 9.0 to 9.5 and recovery of zofenopril in the acidic form; b) salification of acid zofenopril with a potassium salt in alcoholic solution, and recovery of the resulting potassium salt; c) conversion of the potassium salt to the calcium salt by addition of a zofenopril potassium salt aqueous solution to a CaCl2 aqueous solution at a temperature of 70-90°C with simultaneous seeding to promote the precipitation of polymorph A. |
申请公布号 |
YU7501(A) |
申请公布日期 |
2005.06.10 |
申请号 |
YU20010000075 |
申请日期 |
1999.07.30 |
申请人 |
MENARINI RICERCHE S.P.A. |
发明人 |
GIORGI, RAFFAELLO;GIORGI, ALBERTA;GIACHETTI, ANTONIO;MANNUCCI, CARLO |
分类号 |
A61K31/40;A61K31/401;A61P9/04;A61P9/10;A61P9/12;C07D207/16 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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