КОМБИНИРОВАННАЯ ПРОТИВООПУХОЛЕВАЯ ТЕРАПИЯ ЗАМЕЩЕННЫМИ ПРОИЗВОДНЫМИ АКРИЛОИЛДИСТАМИЦИНА И ИНГИБИТОРАМИ ПРОТЕИНКИНАЗ (СЕРИН- /ТРЕОНИНКИНАЗЫ)

摘要

The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and a protein kinase (serine/threonine and tyrosine kinases) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.