发明名称 |
DNA PARTICIPATING IN HYDROXYLATION OF MACROLIDE COMPOUND |
摘要 |
The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, paticularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (I) into a 16-position hydroxy macrolide compound 11107D represented by the formula (II), the DNA encoding a protein having 16-position hydroxylating enzymatic activity or ferredoxin, to a method of isolating the DNA, to a protein encoded by the DNA, a plasmid carrying the DNA, a transformant obtained by transforming using the plasmid and a method of producing a 16-position hydroxy compound by using the transformant. |
申请公布号 |
CA2546614(A1) |
申请公布日期 |
2005.06.09 |
申请号 |
CA20042546614 |
申请日期 |
2004.11.25 |
申请人 |
EISAI CO., LTD.;MERCIAN CORPORATION |
发明人 |
ARITOKU, YASUHIDE;NAKASHIMA, TAKASHI;TSUCHIDA, TOSHIO;MACHIDA, KAZUHIRO |
分类号 |
C12N15/09;C07D407/06;C07K14/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/02;C12N9/10;C12P17/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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