USE OF CRIPTO-1 AS A BIOMARKER FOR NEURODEGENERATIVE DISEASE AND METHOD OF INHIBITING PROGRESSION THEREOF
摘要
A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the Cripto-1 gene product is indicative of a neurodegenerative disease in the mammal; a method of inhibiting progression of a neurodegenerative disease in a mammal, which method comprises administering to the mammal an agent that inhibits Cripto-1 in an amount effective to inhibit Cripto-1 in the central nervous system of the mammal, whereupon the progression of the neurodegenerative disease is inhibited; and an isolated or purified oligonucleotide consisting essentially of the sequence of AAGCTATGGACTGCAGGAAGATGG (SEQ ID NO: 3) or AGAAGGCAGATGCCACTAGC (SEQ ID NO: 4).
申请公布号
WO2005033341(A3)
申请公布日期
2005.06.02
申请号
WO2004US32649
申请日期
2004.10.01
申请人
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;UNIVERSITY OF KANSAS MEDICAL CENTER;SALOMON, DAVID;BERMAN, NANCY;STEPHENS, EDWARD