发明名称 |
NUCLEIC ACID HYBRIDIZATION METHODS |
摘要 |
Disclosed herein are methods of destabilizing double-stranded nucleic acid hybridization using an enzyme comprising DNA N-glycosylase activity. Also disclosed herein is the detection of a double-stranded target DNA wherein the hybridization of duplex strands has been at least partially disrupted thereby permitting invasion of a probe strand. Also disclosed herein are methods of using an enzyme comprising DNA N-glycosylase activity to generate single-stranded circular nucleic acids. |
申请公布号 |
WO2005049848(A2) |
申请公布日期 |
2005.06.02 |
申请号 |
WO2004US37472 |
申请日期 |
2004.11.10 |
申请人 |
GENEOHM SCIENCES, INC.;CROTHERS, DONALD, M. |
发明人 |
CROTHERS, DONALD, M. |
分类号 |
C07H21/04;C12P19/34;C12Q;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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