| 发明名称 |
FACTOR Xa INHIBITORS WITH ARYL-AMIDINES AND DERIVATIVES, AND PRODRUGS THEREOF |
| 摘要 |
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a pharmaceutically acceptable salt, a prodrug, a hydrate, a solvate or an isomer thereof, which are inhibitors of coagulation enzyme, factor Xa (FXa). The present invention also relates to a pharmaceutical composition containing the compound, and a method of using the same as an anticoagulant agent for treatment and prevention of thrombosis disorders. |
| 申请公布号 |
EP1254136(A4) |
申请公布日期 |
2005.06.01 |
| 申请号 |
EP20010901571 |
申请日期 |
2001.01.04 |
| 申请人 |
LG CHEM INVESTMENT, LTD. |
发明人 |
KANG, MYUNG-GYUN;PARK, DOO-HEE;KWON, OH-HWAN;KIM, EUNICE, EUN-KYEONG;HWANG, KWANG-YEON;HEO, YONG-SEOK;PARK, TAE-KYO;LEE, TAE-HEE;MOON, KWANG-YUL;PARK, JONG-WOO;CHANG, HYE-KYUNG;LEE, SANG-KOO;LEE, SUN-HWA;PARK, SU-KYUNG;LEE, SUNG-HACK;PARK, HEE-DONG |
| 分类号 |
C07D213/04;A61K31/155;A61K31/167;A61K31/17;A61K31/18;A61K31/198;A61K31/216;A61K31/27;A61K31/277;A61K31/381;A61K31/40;A61K31/41;A61K31/417;A61K31/4178;A61K31/4196;A61K31/421;A61K31/426;A61K31/44;A61K31/4418;A61K31/4436;A61K31/4439;A61K31/4725;A61K31/5377;A61P7/02;A61P9/00;C07C257/18;C07C259/18;C07C271/20;C07C271/22;C07C271/64;C07C275/24;C07C275/40;C07C275/42;C07C311/06;C07C311/13;C07C311/16;C07C311/19;C07C311/29;C07C311/44;C07C311/46;C07C311/48;C07C317/40;C07C317/44;C07D207/26;C07D207/27;C07D207/32;C07D207/333;C07D207/34;C07D213/40;C07D213/75;C07D213/78;C07D213/81;C07D213/82;C07D213/84;C07D217/22;C07D233/64;C07D233/84;C07D249/12;C07D263/22;C07D263/38;C07D265/10;C07D275/02;C07D277/20;C07D277/56;C07D333/34;C07D333/38;C07D401/10;C07D401/12;C07D403/10;C07D409/06;C07D409/12;C07D413/06;C07D417/06;C07D521/00 |
主分类号 |
C07D213/04 |
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