发明名称 |
Process for the preparation of aerosol compositions |
摘要 |
Formulation comprises a particulate medicament (I) e.g. salmeterol, salbutamol, fluticasone propionate, becolomethasone dipropionate and a fluorocarbon or hydrogen-contg chlorofluorocarbon propellant. Also claimed are the prepn of the surface-modified medicament and a canister for delivering metered doses of the aerosol formulation. Pref., (I) is salmeterol xinafoate (Ia); salbutamol sulphate; fluticascone propionate; beclomethasone dipropionate; or a combination of salmeterol xinafoate and fluticasone propionate; or salbutamol and beclomethasone dipropionate. The propellant is pref. 1,1,1,2-tetrafluoroethane (II). (I) is present in an amt. of 0.005-10% wt. based on the total wt. of the formulation e.g. a salbutamol salt and 1,1,1,2-tetrafluoroethane in a ratio of 0.05:18 by wt. Surface-modified (I) are prepd. by admixture of particulate (I) with a non-polar, non-solvent liq. followed by removal of the lid. |
申请公布号 |
EP1275375(B1) |
申请公布日期 |
2005.06.01 |
申请号 |
EP20020077251 |
申请日期 |
1992.12.04 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
MARRIOT, RACHEL, ANN;TAYLOR, ANTHONY, JAMES;WYATT, DAVID, ANDREW |
分类号 |
A61K47/06;A61K;A61K9/00;A61K9/12;A61K9/72;A61K31/00;A61K31/02;A61K31/135;A61K31/137;A61K31/138;A61K31/167;A61K31/352;A61K31/44;A61K31/4402;A61K31/4458;A61K31/4535;A61K31/4741;A61K31/48;A61K31/522;A61K31/56;A61K31/57;A61K31/573;A61K45/06;A61M11/04;A61M15/00;A61P11/00;A61P11/02;A61P11/06;A61P11/08;B65D83/14;B65D83/52;(IPC1-7):A61K9/00 |
主分类号 |
A61K47/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|