ЖИДКИЙ ПРЕПАРАТ, СОДЕРЖАЩИЙ ПРОИЗВОДНОЕ КАМПОТОТЕЦИНА, И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПОЛУЧАЕМАЯ ПУТЕМ ЛИОФИЛИЗАЦИИ ПРЕПАРАТА

摘要

The present invention relates to a stable liquid preparation comprising a camptothecin derivative which is prepared by binding a compound of the formula [I]: wherein R₁ is a substituted or unsubstituted lower alkyl group, X₁ is a group of the formula: -NHR₂ (R₂ is a hydrogen atom or a lower alkyl group) or a hydroxy group and Alk is a straight or branched chain alkylene group optionally interrupted by an oxygen atom, and a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable sat thereof, which is adjusted to pH 5-8, or a stable pharmaceutical composition produced by lyophilizing said liquid preparation.