6-position substituted indoline, production and use thereof as a medicament

摘要

Disclosed are indolinone compounds of formula (I), wherein: X is O or S, R1 is H, alkoxycarbonyl or alkanoyl, R2 is carboxy, alkoxy-carbonyl, cycloalkoxy-carbonyl, aryloxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, or di-alkylaminocarbonyl, R3 is H, alkyl, cycloalkyl, trifluoromethyl, heteroaryl, phenyl or naphthyl, R4 is cycloalkyl or phenyl, R5 is H or alkyl, The compounds are used in the manufacture of medicaments for treating excessive or anomalous cell proliferation.