发明名称 |
A PRION-LIKE FORM OF CPEB AND RELATED COMPOSITIONS AND METHODS |
摘要 |
The present invention provides methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form. This invention also provides methods for determining the presence and amount of the prion form of CPEB protein in a cell. This invention also provides methods for facilitating the conversion of a non-prion CPEB protein to its prion form. This invention also provides an isolated prion form cytoplasmic polyadenylation element binding (CPEB) protein and compositions comprising a therapeutically effective amount of an agent that facilitates the conversion of CPEB protein from its non-prion form to its prion form, and methods of making such compositions. |
申请公布号 |
WO2005047306(A2) |
申请公布日期 |
2005.05.26 |
申请号 |
WO2004US36781 |
申请日期 |
2004.11.05 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;SI, KAUSIK;KANDEL, ERIC |
发明人 |
SI, KAUSIK;KANDEL, ERIC |
分类号 |
C07K;C07K14/00;C07K14/435;C07K14/47;C12Q1/02;C12Q1/34;C12Q1/68 |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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