发明名称 |
INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA |
摘要 |
Methods of inhibiting fibroblast growth factor receptor 3 and treating vario us conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a compound of Structure I, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I have the following structure where and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting fibroblast growth factor receptor 3 and for use in treating conditions mediated by fibroblast growth factor receptor 3 such as multiple myeloma. |
申请公布号 |
CA2544186(A1) |
申请公布日期 |
2005.05.26 |
申请号 |
CA20042544186 |
申请日期 |
2004.11.05 |
申请人 |
CHIRON CORPORATION |
发明人 |
SHANG, XIAO;MACHAJEWSKI, TIMOTHY D.;RYCKMAN, DAVID;HARWOOD, ERIC;HEISE, CARLA C.;CHOU, JOYCE;CAI, SHAOPEI;ZHU, SHUGUANG;WIESMANN, MARION |
分类号 |
A61K31/496;A61K31/4375;A61K31/4709;A61P35/00;C07D401/04;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D453/02;C07D487/08 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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