DIAGNOSIS AND TREATMENT OF LIVER FIBROSIS

摘要

The present invention provides methods of treatment of liver fibrosis by identification and isolation of polynucleotide sequences, the expression of which is altered in liver fibrosis. The present invention also relates to the use of these isolated polynucleotides and the polypeptides encoded thereby as probes for diagnosis, for screening of treatment modalities and as targets for modulation in liver fibrosis. In particular, the present invention provides methods, compounds and pharmaceutical compositions for the treatment of liver fibrosis. Novel pharmaceutical compositions comprising oligonucleotides or antibodies are also provided.