| 摘要 |
PROBLEM TO BE SOLVED: To provide a quinoline derivative or its pharmacologically acceptable salt having adenosine A<SB>2A</SB>receptor antagonism, etc. SOLUTION: This quinoline derivative expressed by formula (I) (R<SP>1</SP>and R<SP>2</SP>are identical to or different from each other and are each H or a substituted or unsubstituted lower alkyl or the like, and R<SP>3</SP>is cyano, carboxy or the like, or -NR<SP>1</SP>R<SP>2</SP>and -R<SP>3</SP>together form -NR<SP>1B</SP>-A-L-; R<SP>4</SP>is a substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic residue or the like; and R<SP>5</SP>is a substituted or unsubstituted lower alkoxy or the like) or its pharmacologically acceptable salt is provided. COPYRIGHT: (C)2005,JPO&NCIPI
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