发明名称 |
Process for hydroxyazapirones |
摘要 |
This invention describes a process for preparing hydroxyazapirones of Formula I from azapirones of Formula II. The process comprises treating azapirones with a strong base, monitoring enolate formation of the azapirone by IR spectroscopy, and reacting the enolate with a source of molecular oxygen in the presence of a reductant. The process is suitable for large scale production of hydroxyazapirones.
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申请公布号 |
US6897309(B2) |
申请公布日期 |
2005.05.24 |
申请号 |
US20030636070 |
申请日期 |
2003.08.07 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DEPUE JEFFREY;KOTNIS ATUL S.;LEUNG SIMON;DOWDY ERIC D.;WATSON DANIEL J. |
分类号 |
A61K31/495;C07D401/12;C07D401/14;(IPC1-7):C07D401/14 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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