USE OF CRTH2 ANTAGONIST COMPOUNDS IN THERAPY

摘要

Compounds of general formula (I) wherein R<1>, R<2> , R<3> and R<4> are independently hydrogen, halo,C1-C6 alkyl, -O(C1-C6 alkyl), -CON(R<11>)2 , -SO<11>, -SO2R<11>, -SO2N(R<11>)2, -N(R<11>)2, -NR<11>COR<11>, -CO2R<11>, -COR<11>, -SR<11>, -OH, -NO2 or -CN; each R<11> is independently hydrogen or C1 -C6 alkyl; R<5> and R<6> are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached forrn a C3-C7 cycloalkyl group; R<7> is hydrogen or C1-C6 alkyl; R<8> is an aromatic moiety optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, -O(C1-C6)alkyl, -CON(R<11>)2, -SOR<11>, -SO2R<11> , -SO2N(R<11>)2, -N(R<11>)2, -NR<11>COR<11>, -CO2R<11>, -COR<11>, -SR<11>, -OH, -NO2 or -CN; wherein R<11> is as defined above; R<9> is hydrogen, or C1-C6 alkyl; provided that: R<8> is not phenyl substituted with -COOH; when any two of R<1>, R<2> , R<3> and R<4 >are hydrogen, neither of the other two of R<1>, R<2> , R<3> and R<4 >is C3-C6 alkyl; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in the preparation of pharmaceuticals for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.