A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
申请公布号
WO2005022113(A3)
申请公布日期
2005.05.19
申请号
WO2004US22047
申请日期
2004.07.08
申请人
VERTEX PHARMACEUTICALS, INC.;MAHER, MICHAEL, P.;GONZALEZ, III, JESUS, E.