摘要 |
The present invention discloses cloning of tocopherol associated protein TAP-38 and deletion mutants of TAP-46. TAP-38, which shares homology with the previously identified TAP-46, enhances the apoptotic inducing properties of tocopherol based compounds, and blockage of TAP-38 or TAP-46 reduces the effectiveness of tocopherol based compounds. Thus, delivery of TAP-38 and TAP46 cDNA by aerosol liposome/transfection/infection methods, separately or in combination with tocopherol-based apoptosis-inducing agents as well as with other chemotherapeutic agents, would be useful for treatment and prevention of cellular proliferative diseases and disorders. |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION;SANDERS, BOB, G.;KLINE, KIMBERLY;YU, WEIPING;LIU, HUI;HANTASH, FERAS |
发明人 |
SANDERS, BOB, G.;KLINE, KIMBERLY;YU, WEIPING;LIU, HUI;HANTASH, FERAS |