| 发明名称 |
METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE HORMONE RECEPTOR ACTIVITY |
| 摘要 |
The present invention provides methods for identifying an effective agent that modulates a biological activity of a nuclear hormone receptor. In a method of the invention, an isolated receptor-containing complex is assayed for an altered modification state as compared to a control modification state. The presence of an altered modification state serves to identify an effective agent that modulates a biological activity of the nuclear hormone receptor.
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| 申请公布号 |
WO02086062(A9) |
申请公布日期 |
2005.05.19 |
| 申请号 |
WO2002US12159 |
申请日期 |
2002.04.16 |
| 申请人 |
ALLERGAN, INC. |
发明人 |
ZHAO, YI;THACHER, SCOTT, M.;XIAO, JIA-HAO;KUSARI, JYOTIRMOY;CHANDRARATNA, ROSHANTHA, A. |
| 分类号 |
G01N33/68;G01N33/74;G01N33/78;(IPC1-7):C07H21/04;C07K14/705;C12N15/09;C12N15/63;C12Q1/68 |
主分类号 |
G01N33/68 |
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