| 发明名称 |
Nucleic acids |
| 摘要 |
Polypeptides, in particular the polypeptide of formula I: <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="1"> <colspec colname="1" colwidth="217pt" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY>Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-</ENTRY> </ROW> <ROW> <ENTRY>Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-</ENTRY> </ROW> <ROW> <ENTRY>Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-</ENTRY> </ROW> <ROW> <ENTRY>Asp-Cys-Pro-Gly-Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-</ENTRY> </ROW> <ROW> <ENTRY>Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln</ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES> and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
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| 申请公布号 |
US6893843(B2) |
申请公布日期 |
2005.05.17 |
| 申请号 |
US20010833799 |
申请日期 |
2001.04.13 |
| 申请人 |
CHRISTOPHERS ENNO;WIEDOW OLIVER;SCHRODER JENS-MICHAEL;EDGE MICHAEL DEREK;PIOLI DAVID |
发明人 |
CHRISTOPHERS ENNO;WIEDOW OLIVER;SCHRODER JENS-MICHAEL;EDGE MICHAEL DEREK;PIOLI DAVID |
| 分类号 |
A61K38/00;A61K38/55;A61P11/00;A61P17/00;A61P37/00;C07K1/20;C07K14/00;C07K14/39;C07K14/435;C07K14/47;C07K14/81;C07K16/00;C07K16/18;C07K16/38;C12N1/19;C12N1/21;C12N9/99;C12N15/09;C12N15/15;C12N15/81;C12P21/02;C12P21/08;C12R1/19;C12R1/865;(IPC1-7):C12N15/09;C12N15/74;C07H21/02 |
主分类号 |
A61K38/00 |
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