发明名称 |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl IV, processes for their preparation, and their use |
摘要 |
<p>Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H; and wherein R 1 , R 2 , R 3 and R 4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity and/or other therapeutic agent.</p> |
申请公布号 |
AU2001245466(B2) |
申请公布日期 |
2005.05.12 |
申请号 |
AU20010245466 |
申请日期 |
2001.03.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DAVID A BETEBENNER;LAWRENCE G HAMANN;DAVID R. MAGNIN;DAVID J. AUGERI;RICHARD B. SULSKY;JEFFREY A. ROBL |
分类号 |
C07D401/06;A61K31/403;A61K31/4045;A61K31/454;A61K45/00;A61P1/00;A61P1/04;A61P3/00;A61P3/04;A61P3/06;A61P3/08;A61P3/10;A61P9/10;A61P15/00;A61P19/02;A61P19/10;A61P25/18;A61P31/18;A61P37/02;A61P37/06;A61P43/00;C07C271/12;C07D209/52;C07D403/06;(IPC1-7):C07D209/52;A61P003/06;A61P003/04;A61P003/10;A61K031/403 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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