| 摘要 |
PROBLEM TO BE SOLVED: To provide an elucidation of a target gene of a PGI2-PPARδtransmission system and a new inflammatory disease-treating agent by taking the PGI2-PPARδtransmission system as the target. SOLUTION: This target of the PG (prostaglandin) I2-PPAR (peroxisome proliferator-activated receptor)δtransmission system is found to be an IL (interleukin)-13 gene by a microarray analysis. The association of a PGI2-PPARδ-IL-13 pathway with cellular adhesion is examined, and a fact that the production of the IL-13 mediated by the PPARδinhibits the adhesion of monocytes with endothelium cells markedly is elucidated. The association between the PGI2-PPARδ-IL-13 pathway and COX (cyclooxygenase)-2 is examined, and it is found that the IL-13 production mediated by PGI2/PPARδinhibits the expression of the COX-2. It is known that the monocyte-endothelium cell adhesion and COX-2 are related to the inflammation. Therefore, it is possible to use a cell adhesion inhibitor or COX-2 inhibitor by taking the PGI2-PPARδ-IL-13 pathway as the target can be utilized as an anti-inflammatory agent. COPYRIGHT: (C)2005,JPO&NCIPI
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