Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
申请公布号
WO2004035605(A3)
申请公布日期
2005.05.12
申请号
WO2003US32870
申请日期
2003.10.15
申请人
THE SCRIPPS RESEARCH INSTITUTE;SCHULTZ, PETER, G.;WANG, LEI;ZHANG, ZHIWEN