(4-PHENYL) PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
摘要
The invention relates to substituted piperidine piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.
申请公布号
KR20050044533(A)
申请公布日期
2005.05.12
申请号
KR20047007631
申请日期
2004.05.19
申请人
PHARMACIA AND UPJOHN COMPANY LLC;ELAN PHARMACEUTICALS, INC.