POLYMERIC COMPOSITION FOR DRUG DELIVERY

摘要

Polymeric compositions capable of forming stable micelles in an aqueous solution, comprising an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block wherein the hydroxyl terminal group is substituted with a tocopherol or cholesterol group, and a polylactic acid derivative wherein one end of the polylactic acid is covalently bound to at least one carboxyl group, and wherein the carboxyl group of the polylactic acid derivative may be fixed with a di- or tri-valent metal ion by adding the di- or tri-valent metal ion to the polymeric composition.