发明名称 |
LIGAND-PSEUDORECEPTOR SYSTEM FOR GENERATION OF ADENOVIRAL VECTORS WITH ALTERED TROPISM |
摘要 |
<p>In accordance with the present invention, there is provided a modified virus ablated of its natural receptors interactions with an unmodified or non-naturally occurring cell, said modified virus comprising a non-native polypeptide, said modified virus having an altered tropism conferred by said non-native peptide, and replicating only in cells that can interact with said non-native peptide, said virus being incapable of infecting a cell through a CAR-dependent entry pathway. There is also provided a modified cell line for replicating the modified virus. These two together can be advantageously put into practice in the field of medicine and more particularly in gene therapy.</p> |
申请公布号 |
CA2543200(A1) |
申请公布日期 |
2005.05.06 |
申请号 |
CA20042543200 |
申请日期 |
2004.10.22 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
MASSIE, BERNARD;O'CONNOR-MCCOURT, MAUREEN;ZENG, YUE |
分类号 |
C12N7/01;A61K48/00;C07K14/075;C07K14/245;C07K14/705;C07K14/71;C12N;C12N5/10;C12N15/861 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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