发明名称 |
TECHNIQUES TO TREAT NEUROLOGICAL DISORDERS BY ATTENUATING THE PRODUCTION OF PRO-INFLAMMATORY MEDIATORS |
摘要 |
Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject. |
申请公布号 |
WO2005039393(A2) |
申请公布日期 |
2005.05.06 |
申请号 |
WO2004US35194 |
申请日期 |
2004.10.22 |
申请人 |
MEDTRONIC, INC.;SHAFER, LISA, L. |
发明人 |
SHAFER, LISA, L. |
分类号 |
A61B;A61K9/22;A61K39/395;A61M5/142;A61M5/172;A61M39/02;C07K16/24;G01N33/53 |
主分类号 |
A61B |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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