发明名称 POLYMER CONJUGATES OF PROTEIN KINASE C INHIBITORS
摘要 The invention provides polymer conjugates of protein kinase C (PKC) inhibitors comprising a polymer, such as poly(ethylene glycol), covalently attached to a PKC inhibitor, such as a bisindolylmaleimide molecule. The linkage between the polymer and the PKC inhibitor is preferably hydrolytically degradable. The invention also includes a pharmaceutical composition comprising a polymer conjugate of a PKC inhibitor and a method of treating any condition responsive to a PKC inhibitor by administering a polymer conjugate of the invention.
申请公布号 KR20050040832(A) 申请公布日期 2005.05.03
申请号 KR20047006368 申请日期 2004.04.29
申请人 NEKTAR THERAPEUTICS AL, CORPORATION 发明人 ZHAO, XUAN;BENTLEY, MICHAELDAVID
分类号 C07D403/14;A61K31/404;A61K45/00;A61K47/48;A61P3/10;A61P9/00;A61P11/06;A61P17/06;A61P25/28;A61P29/00;A61P31/12;A61P35/00;A61P37/00;A61P43/00;C08G65/333;(IPC1-7):A61K47/48 主分类号 C07D403/14
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