AMIDE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3-BETA INHIBITORS

摘要

This invention concerns a compound of formula (I'),a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10 alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C 2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1- 6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6 alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21-C1-6alkyl; R21-O-; R 21-S-; R21-C(=O)-; R21-S(=O)p-; R 7-S(=O)p-; R7-S(=O)p-NH-; R21- S(=O)p-NH-; R7-C(=O)-; -NHC(=O)H;-C(=O)NHNH2; R7-C(=O)-NH-; R21-C(=O)-NH-; -C(=NH)R7; -C(=NH) R21 ; R4a or R4b each independently represent hydrogen, R8, -Y1-NR9-Y2-NR10 R11, -Y1-NR9-Y1-R8, -Y 1-NR9R10; provided that -X-R2 and/or R 3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.