发明名称 |
PREPARATION OF CIS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7] YKLOHEPTA[1,2-b]FURAN |
摘要 |
The present invention concerns a process for preparing each of the 4 individual diastereomers of formula (I) in stereochemically pure form from a single enantiomerically pure precursor. The tetracyclic ringsystem having cis-fused five and seven membered rings is formed in a base-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates and methanamine end-products, and the methanamine end-products for use as a medicine, in particular as CNS active medicines |
申请公布号 |
HRP20040489(A2) |
申请公布日期 |
2005.04.30 |
申请号 |
HR2004P000489 |
申请日期 |
2004.05.31 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
HUA MAO;TOMASZ KOZLECKI;COMPERNOLLE FRANS JOSEF CORNEL;HOORNAERT GEORGES JOSEF CORNEL |
分类号 |
A61K31/34;A61K31/343;A61P25/00;A61P25/06;A61P25/18;A61P25/22;A61P25/24;A61P25/30;C07D307/93 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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