| 摘要 |
THE INVENTION RELATES TO NEW COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES, THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS AS ACTIVE INGREDIENTS AND THE USE OF THE COMPOUNDS AS THROMBIN INHIBITORS, ANTICOAGULANTS AND ANTIINFLAMMATORY INHIBITORS FOR PROPYLAXIS AND TREATMENT OF RELATED DISEASES, ACCORDING TO THE FORMULAA1---------------A2------------NH----(CH2)N-----------BFORMULA IA1---------------A2------------NH----(CH2)N-----------B------DFORMULA VWHEREIN A1 REPRESENT A STRUCTURAL FRAGMENT OF FORMULASFORMULA IIA, IIB, IIC, IID, IIEA² REPRESENT A STRUCTURAL FRAGMENT OF FORMULASFORMULA IIIA, IIIB, IIICB REPRESENT A STRUCTURAL FRAGMENT OF FORMULASFORMULA IVA, IVB, IVC, IVDFURTHER DESCRIBED IS NOVEL COMPOUNDS, THE NEW USE OF COMPOUNDS AND ESPECIALLY NEW STRUCTURAL FRAGMENT IN SYNTHESIS OF PHARMACEUTICAL COMPOUNDS.
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