Synthetic method for the fluoromethylation of alcohols

摘要

A method for fluoromethylating halogenated alcohols, comprising the steps of: (a) reacting a halogenated alcohol with a dialkoxymethane of formula CH2(OR)2 to form an acetal compound, wherein R is alkyl, alkenyl or alkynyl, (b) chlorinating the acetal compound with a chlorinating agent to form a chloromethyl ether, and (c) fluorinating the chloromethyl ether to a fluoride with a fluorinating agent to form a fluorinated haloalcohol.