发明名称 |
Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia |
摘要 |
Described is an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80 % of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.
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申请公布号 |
NZ527408(A) |
申请公布日期 |
2005.04.29 |
申请号 |
NZ20010527408 |
申请日期 |
2001.04.20 |
申请人 |
SKYEPHARMA CANADA INC |
发明人 |
GUIVARC'H, POL-HENRI;PARIKH, INDU;SNOW, ROBERT A |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K9/26;A61K9/32;A61K9/48;A61K31/216;A61K31/22;A61K31/365;A61K31/366;A61K31/40;A61K31/404;A61K31/405;A61K31/44;A61K31/4418;A61K31/505;A61K31/66;A61K38/00;A61K45/06;A61K47/24;A61K47/26;A61P3/00;A61P3/06;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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