It has been found that Toll-like receptor 1 and Toll-like receptor 2 (TLR2) physically interact. Antibodies that specifically bind to TLR2 and selectively inhibit induction of cytokines are also described. The invention relates to specific antibodies that selectively bind to TLR2, and to methods of identifying compounds that selectively interfere with signaling through TLR1/TLR2 complexes.
申请公布号
WO2005019431(A3)
申请公布日期
2005.04.28
申请号
WO2004US27322
申请日期
2004.08.20
申请人
UNIVERSITY OF MASSACHUSETTS;KURT-JONES, EVELYN, A.;FINBERG, ROBERT, W.