FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

摘要

A compound of formula: (I); or a salt, solvate and chemically protected form thereof, wherein one of R<2> and R<5> is: (i) H or an optionally substituted C1-4 alkyl group; or (ii)an optionally substituted C5-7 aryl; and the other of R<2> and R<5> is the other group; m and n can be 0 or 1, and m + n = 1 or 2 R<N> is H or optionally substituted C1-4 alkyl R<3> is either: (i) carboxy; (ii) a group of formula: (II); (iii) a group of formula: (III); wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NR<N3>R<N4> , where R<N3> and R<N4> are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.