The present invention relates to soluble, recombinant CD40L variant proteins that may be expressed solubly in E. coli. The variants of the present invention may substantially reduced binding to alpha IIb-beta3 integrin, act as CD40L antagonists or agonists, and methods for generating the same.
申请公布号
WO2005035570(A2)
申请公布日期
2005.04.21
申请号
WO2004US33707
申请日期
2004.10.12
申请人
XENCOR, INC.;CHAMBERLAIN, AARON, KEITH;DESJARLAIS, JOHN, R.;MOORE, GREGORY, L.
发明人
CHAMBERLAIN, AARON, KEITH;DESJARLAIS, JOHN, R.;MOORE, GREGORY, L.
